Publicaciones científicas

Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases

A Cienfuegos J (1), Baixauli J (2), Arredondo J (3), Pastor C (4), Martínez Ortega P (5), Zozaya G (6), Martí-Cruchaga P (7), Hernández Lizoáin JL (8)

(1) Cirugía/ Apoyo Investigación, Clinica Universidad de Navarra, España.
(2) Cirugía General, Clínica Universidad de Navarra , España.
(3) Cirugía General, Complejo Hospitalario de León, España.
(4) Cirugía General y Digestiva, Hospital Universitario Fundación Jiménez Díaz, España.
(5) Cirugía General y Digestiva, Centro Médico de Asturias.
(6) General Surgery, Clinica Universidad de Navarra, España.
(7) Cirugía General y Digestiva, Clínica Universidad de Navarra, España.
(8) General Surgery, Clínica Universidad de Navarra, España.

Revista: Revista Española de Enfermedades Digestivas

Fecha: 18-dic-2017

Cirugía General y Digestiva

PURPOSE:

The objective of the study was to analyze the clinico-pathological differences and the oncologic outcomes between right and left-sided colon cancer.

PATIENTS AND METHODS:

The patients cohort was identified from a prospective register of colon cancer, 950 patients underwent surgery (stages I, II and III)), of which 431 had right-sided colon cancer and 519 had left-sided colon cancer.

RESULTS:

More laparoscopic resections were performed (101 vs 191; p < 0.001) and operating times were longer (146 min vs 165 min; p < 0.001) in the left-sided colon group.

Patients with right-sided colon cancer more frequently received transfusions (18.8% vs 11.3%; p < 0.001) and experienced a greater number of complications (28.5% vs 20.9%, p = 0.004), although severity and operative mortality were similar in both groups (1.2% vs 0.2%).

Mucinous adenocarcinomas and undifferentiated tumors were more frequent in the right-sided group (12% vs 6.5%; p < 0.001). Early stage was predominant in the left-sided colon tumors (28.2% vs 34.5%, p = 0.02). There were no differences in disease-free survival (DFS) in stages I and II after a median follow-up of 103 months. However, a greater survival at five and ten years in left-sided, stage III tumors was observed, with a trend towards statistical significance (p = 0.06). No differences were found with regard to the patterns of recurrence.

CONCLUSIONS:

Right-sided colon cancer exhibits phenotypical differences with regard to left-sided colon cancer. In stage III disease, left-sided colon cancer has a greater survival with a trend towards statistical significance. Overall, tumor location is a variable that should be taken into consideration in clinical studies of colon cancer.

CITA DEL ARTÍCULO  Rev Esp Enferm Dig. 2017 Dec 18;110. doi: 10.17235/reed.2017.5034/2017

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