Publicaciones científicas

4-1BB (CD137) in anticancer chimeras

07-dic-2020 | Revista: The Journal of Experimental Medicine

Ignacio Melero  1   2   3   4 , Pedro Berraondo  1   2  3


Abstract

4-1BB (CD137, TNFRSF9) mediates costimulatory signals important for activation and persistence of cytotoxic T lymphocytes. In this issue of JEM, Oda et al. (https://doi.org/10.1084/jem.20191166) report on a chimeric construction encompassing extracellular Fas and intracellular 4-1BB to dramatically improve adoptive T cell therapy.

CITA DEL ARTÍCULO J Exp Med. 2020 Dec 7;217(12):e20201562.  doi: 10.1084/jem.20201562