PUBLICAÇÕES científicas

Emphysema phenotypes and lung cancer risk

González J (1), Henschke CI (2), Yankelevitz DF (2), Seijo LM (1), Reeves AP (3,4), Yip R (2), Xie Y (3), Chung M (2), Sánchez-Salcedo P (5), Alcaide AB (1), Campo A (1), Bertó J (1), Del Mar Ocón M (1), Pueyo J (6), Bastarrika G (6), de-Torres JP (1,7), Zulueta JJ (1,7,8,9).

(1) Pulmonary Service, Clínica Universidad de Navarra, Pamplona, Spain.
(2) Department of Radiology Mount Sinai School of Medicine, NY, United States of America.
(3) School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, United States of America.
(4) Vision, Inc, Ithaca, NY, United States of America.
(5) Pulmonary Service, Complejo Hospitalario de Navarra, Pamplona, Spain.
(6) Radiology Department, Clínica Universidad de Navarra, Pamplona, Spain.
(7) Navarra's Health Research Institute (IDISNA), Pamplona, Spain.
(8) CIBERONC, ISCIII, Madrid, Spain.
(9) VisionGate, Inc, Phoenix, Arizona, United States of America.

Revisão:PLoS One

Data: 25/Jul/2019

Radiología [ES] Pneumologia

BACKGROUND:

To assess the relationship between lung cancer and emphysema subtypes.

OBJECTIVE:

Airflow obstruction and emphysema predispose to lung cancer. Little is known, however, about the lung cancer risk associated with different emphysema phenotypes. We assessed the risk of lung cancer based on the presence, type and severity of emphysema, using visual assessment.

METHODS:

Seventy-two consecutive lung cancer cases were selected from a prospective cohort of 3,477 participants enrolled in the Clínica Universidad de Navarra's lung cancer screening program. Each case was matched to three control subjects using age, sex, smoking history and body mass index as key variables. Visual assessment of emphysema and spirometry were performed. Logistic regression and interaction model analysis were used in order to investigate associations between lung cancer and emphysema subtypes.

RESULTS:

Airflow obstruction and visual emphysema were significantly associated with lung cancer (OR = 2.8, 95%CI: 1.6 to 5.2; OR = 5.9, 95%CI: 2.9 to 12.2; respectively). Emphysema severity and centrilobular subtype were associated with greater risk when adjusted for confounders (OR = 12.6, 95%CI: 1.6 to 99.9; OR = 34.3, 95%CI: 25.5 to 99.3, respectively). The risk of lung cancer decreases with the added presence of paraseptal emphysema (OR = 4.0, 95%CI: 3.6 to 34.9), losing this increased risk of lung cancer when it occurs alone (OR = 0.7, 95%CI: 0.5 to 2.6).

CONCLUSIONS:

Visual scoring of emphysema predicts lung cancer risk. The centrilobular phenotype is associated with the greatest risk.

CITAÇÃO DO ARTIGO  PLoS One. 2019 Jul 25;14(7):e0219187. doi: 10.1371/journal.pone.0219187. eCollection 2019

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra