Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases
A Cienfuegos J (1), Baixauli J (2), Arredondo J (3), Pastor C (4), Martínez Ortega P (5), Zozaya G (6), Martí-Cruchaga P (7), Hernández Lizoáin JL (8)
(1) Cirugía/ Apoyo Investigación, Clinica Universidad de Navarra, España.
(2) Cirugía General, Clínica Universidad de Navarra , España.
(3) Cirugía General, Complejo Hospitalario de León, España.
(4) Cirugía General y Digestiva, Hospital Universitario Fundación Jiménez Díaz, España.
(5) Cirugía General y Digestiva, Centro Médico de Asturias.
(6) General Surgery, Clinica Universidad de Navarra, España.
(7) Cirugía General y Digestiva, Clínica Universidad de Navarra, España.
(8) General Surgery, Clínica Universidad de Navarra, España.
Revisão:Revista Española de Enfermedades Digestivas
Data: 18/Dez/2017Cirurgia Geral e Digestiva
The objective of the study was to analyze the clinico-pathological differences and the oncologic outcomes between right and left-sided colon cancer.
PATIENTS AND METHODS:
The patients cohort was identified from a prospective register of colon cancer, 950 patients underwent surgery (stages I, II and III)), of which 431 had right-sided colon cancer and 519 had left-sided colon cancer.
More laparoscopic resections were performed (101 vs 191; p < 0.001) and operating times were longer (146 min vs 165 min; p < 0.001) in the left-sided colon group.
Patients with right-sided colon cancer more frequently received transfusions (18.8% vs 11.3%; p < 0.001) and experienced a greater number of complications (28.5% vs 20.9%, p = 0.004), although severity and operative mortality were similar in both groups (1.2% vs 0.2%).
Mucinous adenocarcinomas and undifferentiated tumors were more frequent in the right-sided group (12% vs 6.5%; p < 0.001). Early stage was predominant in the left-sided colon tumors (28.2% vs 34.5%, p = 0.02). There were no differences in disease-free survival (DFS) in stages I and II after a median follow-up of 103 months. However, a greater survival at five and ten years in left-sided, stage III tumors was observed, with a trend towards statistical significance (p = 0.06). No differences were found with regard to the patterns of recurrence.
Right-sided colon cancer exhibits phenotypical differences with regard to left-sided colon cancer. In stage III disease, left-sided colon cancer has a greater survival with a trend towards statistical significance. Overall, tumor location is a variable that should be taken into consideration in clinical studies of colon cancer.
CITAÇÃO DO ARTIGO Rev Esp Enferm Dig. 2017 Dec 18;110. doi: 10.17235/reed.2017.5034/2017
A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.
Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.
Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.