Publicaciones científicas

Use of recombinant activated factor VII (Novoseven) in trauma and surgery: analysis of outcomes reported to an international registry

Grounds RM, Seebach C, Knothe C, Paluszkiewicz P, Smith TS, Kasal E, Lecumberri R, Urbanec R, Haas T, Wujtewicz M, Rehorkova D, Pelichovska M, Lange M, Uranga M, Bosman R, Rommes JH, Koscielny J.
Anaesthesia and Intensive Care Medicine, St George's Hospital, Tooting, London, UK

Revista: Journal of Intensive Care Medicine

Fecha: 01/02/2006

Hematología y Hemoterapia

The objective was to evaluate the efficacy and safety of recombinant activated factor VII in patients with massive bleeding.

Forty-five patients with severe massive hemorrhage requiring>or= 14 transfusion units of packed red blood cells received recombinant activated factor VII. Postdrug blood loss and transfusion requirements were assessed, and mortality was compared with predicted outcomes.

Blood loss was markedly reduced in 40 of 43 (93.0%) patients, and transfusion requirements decreased after recombinant activated factor VII administration. Mortality rate in trauma patients who had massive hemorrhage was significantly reduced compared with predictions using scoring systems. This may be associated with the use of recombinant activated factor VII.

This study failed to demonstrate an improvement in surgical patients. The absence of concurrent controls prevents definitive conclusions regarding actual safety or efficacy of recombinant activated factor VII.

CITA DEL ARTÍCULO  J Intensive Care Med. 2006 Jan-Feb;21(1):27-39

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