Publicaciones científicas

Cost-effectiveness of selective internal radiation therapy using yttrium-90 resin microspheres in treating patients with inoperable colorectal liver metastases in the UK

Pennington B (1), Akehurst R (2), Wasan H (3), Sangro B (4), Kennedy AS (5), Sennfält K (6), Bester L (7).
(1a) BresMed , Sheffield , UK.
(2b) University of Sheffield , Sheffield , UK.
(3c) Medical Oncology, Hammersmith Hospital, Imperial NHS Trust , London , UK.
(4d) Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain; and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD) , Pamplona , Spain.
(5e) Radiation Oncology, Sarah Cannon Research Institute , Nashville , TN , USA.
(6f) Sirtex Medical Limited , North Sydney , NSW , Australia.
(7g) Interventional Radiology, University of New South Wales, St. Vincent's Hospital , Darlinghurst , NSW , Australia. 

Revista: Journal of Medical Economics

Fecha: 09/06/2015

Hepatología

OBJECTIVE:
Selective internal radiation therapy (SIRT) using SIR-Spheres(®) (90)Y-labeled resin microspheres has been shown to be a well-tolerated, effective treatment in patients with inoperable liver-dominant chemotherapy-refractory metastatic colorectal cancer (mCRC). This study estimated the cost-effectiveness of (90)Y-resin microspheres compared to best supportive care (BSC) from a UK perspective.

METHODS:
Survival data from a comparative retrospective cohort study was analyzed and used in a state-transition cost-effectiveness model, using quality-adjusted life years (QALYs) gained as the measure of effectiveness. The model incorporated costs for the SIRT procedure, monitoring, further treatment, adverse events, and death. Utility values, reflecting patient quality-of-life, were taken from a published source.

RESULTS:
SIRT using (90)Y-resin microspheres compared to BSC improved overall survival by a mean of 1.12 life years and resulted in a cost per QALY gained of £28,216. In sensitivity analysis, this varied between £25,015-£28,817.

CONCLUSION:
In an area of large unmet need, treatment with (90)Y-resin microspheres offers a clinically effective and cost-effective treatment option.

CITA DEL ARTÍCULO  J Med Econ. 2015;18(10):797-804. doi: 10.3111/13696998.2015.1047779. Epub 2015 Jun 9.

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra