Dra. María José Cuadrado Lozano

ÁREAS DE INVESTIGACIÓN

Sus principales áreas de investigación son:

• Aspectos clínicos y de tratamiento en el Lupus eritematoso sistémico
• Mecanismos de trombosis y tratamiento del Síndrome Antifosfolipido
• Aspectos clínicos y de tratamiento en el embarazo de las enfermedades autoinmunes sistémicas.

Este interés se ve reflejado en los proyectos de investigación en los que ha trabajado, apoyados con financiación pública o privada y en sus publicaciones.

Becas
1991: Main investigator: De Ramon E,Co-applicants: Camps MT, Cuadrado MJ, Nebro A."Immunogenetics aspects of connective tissue disease and its relationship with antibodies sintesis and clinical events".
1992: Main Investigator: Cuadrado MJ. "Systemic Lupus Erythematosus and Antiphospholipid syndrome: clinical and terapeutic aspects". (St. Thomas' Hospital, London U.K.).
1993: Main investigator: De Ramon E,Co-applicants: Camps MT, Cuadrado MJ, Nebro A."Systemic lupus erythematosus: Outcome and survival".
1995: Main Investigator: Cuadrado MJ.Co-applicants: de Ramon E, camps MT, Tinahones F, Khamashta MA, Hughes GRV "b2-glycoprotein I in Systemic lupus erythematosus and Antiphospholipid syndrome: Correlation with clinical events".
1997: Main Investigator: Cuadrado MJ. Co-applicants: Camps MT, Tinahones F, Aguirre MA, Khamashta MA, Hughes GRV Tissue Factor pathway in primary antiphospholipid.
2000-2006: Main Investigator: Khamashta MA. Co-ordinator: Cuadrado MJ."A prospective, multi-centre, randomised trial, comparing low-dose aspirin with low-dose aspirin plus low-intensity oral anticoagulation in the primary prevention of thrombosis in patients positive for antiphospholipid antibodies".
2001-2003: Expression of transcription factors NfkappaB and its inhibitor IkappaB in patients with antiphospholipid syndrome.
2003-2006 Molecular expression of tissue factor in monocytes from patients with antiphospholipid syndrome: role of statins as antithrombotic therapy.
2007-2010 Effect of statins and antioxidants in cellular and molecular mechanisms in patients with APS and SLE.
2007-2010 Immunogenetic susceptibility and metabolic alterations as etiopathogenic factors of chronic pain in patients with Sjogren’s syndrome in comparison with primary health care patients.
2009-2011: Mitochondrial dysfunction and oxidative stress in atherothrombosis associated with systemic autoimmune diseases. Genomic and proteomic analysis.
2011-2014: New oral anticoagulants for the treatment of patients with thrombotic antiphospholipid syndrome: a prospective pilot randomised controlled trial of warfarin versus rivaroxaban. Arthritis Research UK. Co-investigator.

ÁREAS DE INTERÉS

• Lupus eritematoso sistémico
• Síndrome antifosfolípido
• Seguimiento del embarazo en mujeres con enfermedades autoinmunes