Publicaciones científicas

Chronic inflammatory demyelinating polyneuropathy associated with metastatic malignant melanoma of unknown primary origin

José-Alberto Palma (1) and Salvador Martín-Algarra (2)
(1) Department of Neurology, University Clinic of Navarra, Av. Pio XII 36, 31008 Pamplona, Spain
(2) Department of Oncology, University Clinic of Navarra, Av. Pio XII 36, 31008 Pamplona, Spain

Revista: Journal of Neuro-Oncology

Fecha: 01/09/2009

Oncología Médica

Paraneoplastic neurological syndromes (PNS) are rare manifestations of malignant disease. It is currently believed that most, if not all, PNS are autoimmune in nature.

Proteins expressed on the surface of tumor cells trigger an immune response that cross-reacts with similar proteins in the nervous system, resulting in damage. Moreover, recent studies propose that the appearance of autoimmune phenomena in patients with malignant melanoma implies a strong antitumoral activity and constitutes a marker of improvement in overall survival. We describe a most unusual case of chronic inflammatory demyelinating polyneuropathy (CIDP) occurring in a patient with metastatic malignant melanoma of unknown primary origin who received treatment with interferon alpha-2b.

We also review the relevant literature about this infrequent association, discuss on its pathogenesis and underline its importance as surrogate marker, useful to verify the antineoplastic treatment efficacy.

CITA DEL ARTÍCULO  J Neurooncol. 2009 Sep;94(2):279-81

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra