Publicaciones científicas

Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders

Valerie Voon (a), Pierre-Olivier Fernagut (b), Jeff Wickens (c), Christelle Baunez (d), Manuel Rodríguez (e), Nancy Pavon (f), Jorge L. Juncos (g), José A. Obeso (e), Erwan Bezard (b)
(a) Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
(b) Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France
(c) Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12?22 Suzaki, Uruma City, Okinawa, Japan
(d) Laboratoire de Neurobiologie de la Cognition, CNRS UMR 6155, Aix-Marseille Université, Marseille, France
(e) Clínica Universidad de Navarra, Pamplona, Spain

Revista: The Lancet Neurology

Fecha: 01/12/2009

Neurología

Dopamine is an essential neurotransmitter for many brain functions, and its dysfunction has been implicated in both neurological and psychiatric disorders.

Parkinson's disease is an archetypal disorder of dopamine dysfunction characterised by motor, cognitive, behavioural, and autonomic symptoms. While effective for motor symptoms, dopamine replacement therapy is associated not only with motor side-effects, such as levodopa-induced dyskinesia, but also behavioural side-effects such as impulse control disorders (eg, pathological gambling and shopping, binge eating, and hypersexuality), punding (ie, abnormal repetitive non-goal oriented behaviours), and compulsive medication use. We review clinical features, overlapping molecular mechanisms, and a specific cognitive mechanism of habit learning that might underlie these behaviours.

We integrate these mechanisms with the emerging view of the basal ganglia as a distributive system involved in the selection and facilitation of movements, acts, and emotions.

CITA DEL ARTÍCULO  Lancet Neurol. 2009 Dec;8(12):1140-9

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra