Relationship between Thyroid-Stimulating Hormone and Insulin in Euthyroid Obese Men
J.C. Galofré (a), P. Pujante (a), C. Abreu (a), S. Santos (a), F. Guillen-Grima (b), G. Frühbeck (a,c), J. Salvador (a)
Departments of (a) Endocrinology
(b) Preventive Medicine, University Clinic
(c) Metabolic Research Laboratory, Faculty of Medicine, University of Navarra, Pamplona, Spain
Magazine: Annals of Nutrition and Metabolism
Date: Aug 1, 2008Preventive Medicine [SP] Endocrinology and Nutrition [SP]
Obesity has been associated with hypothyroidism and impaired insulin sensitivity. However, few studies have specifically addressed the association between insulin sensitivity and thyroid function. Our aim was to look for a relation between these 2 factors in a sample of obese males.
One hundred and forty-four euthyroid male obese patients--mean age 42.6 years, mean body mass index (BMI) 41.8--were enrolled in this cross-sectional study. The hospital study protocol at entrance included baseline serum thyroid-stimulating hormone (TSH), insulin and glucose concentrations. Data were studied using an age-adjusted simple and multivariate linear regression analysis with TSH as the dependent and insulin and BMI as the independent variables.
Mean TSH and insulin were 1.6 and 21.2 mU/l, respectively. It was found that their relationship follows a regression model: TSH=1.725-0.019 (age) + 0.003 (insulin) + 0.017 (BMI). Further data showed a positive correlation between BMI and TSH (r= 0.22; p<0.05), as well as between serum baseline insulin (>10 mU/l) and TSH concentration (r=0.27; p<0.05). This association was stronger in patients with higher insulin values (>21.2 mU/l; r=0.40; p<0.01). However, negative correlations between age and insulin (r= -0.14; not significant) and age and TSH (r= -0.35; p<0.05) were observed.
In obese males, insulin resistance is significantly related with impairment of thyroid function, and this situation seems to be attenuated with age.
CITATION Ann Nutr Metab. 2008;53(3-4):188-94
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