Factors determining the actual received dose intensity in a program of multicyclic dose-intensive alternating chemotherapy with sequential stem cell support
Pérez-Calvo J., Martínez-Aguillo M., García-Rayo S., Ramón y Cajal T., Santisteban M., Ordóñez J.M., Inogés S. [SP], Subirá M.L., Martín-Algarra S., Brugarolas A.
Department of Oncology and Cell Therapy Area, Clínica Universitaria de Navarra, Pamplona, Spain.
Magazine: Acta Haematologica
Date: Jan 1, 2001Medical Oncology Breast Cancer Area Cell Therapy Area [SP]
Dose intensity has been related to clinical outcome in several solid tumors. We studied the influence of clinical and cellular parameters on dose intensity received in a series of 53 patients with metastatic breast cancer or advanced ovarian cancer.
They received courses of cisplatin 120 mg/m(2) plus etoposide 600 mg/m(2) alternating every 14 days with ifosfamide 8 g/m(2) plus paclitaxel 200--350 mg/m(2). Blood stem cell support was administered after every course except for the first one. Patients with excellent mobilization underwent immunomagnetic selection of CD34+ cells. We found a significant inverse correlation between the CD34+ cell dose infused and the delay for the administration of the next cycle. A CD34+ cell dose between 1.5 and 5 x 10(6)/kg per cycle was found to be feasible and was followed by a median delay of 1 day (not different from doses above 5 x 10(6)/kg).
Three factors independently predicted the actually received dose intensity in a multiple regression model (R(2) = 0.4): previous autologous transplantation, eligibility for immunomagnetic selection (excellent response to mobilization) and median CD34+ cell dose received along the treatment.
CITATION Acta Haematol. 2001;105(3):137-42
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