Scientific publications

Design and Performance of a New Severity Score for Intermediate Care

Alegre F [SP](1), Landecho MF(2) [SP], Huerta A(1) [SP], Fernández-Ros N(1), Martínez-Urbistondo D(1), García N(1) [SP], Quiroga J(3) [SP], Lucena JF(1) [SP].

(1) Division of Intermediate Care and Hospitalists Unit, Department of Internal Medicine, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
(2) Division of Intermediate Care and Hospitalists Unit, Department of Internal Medicine, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain.
(3) Division of Intermediate Care and Hospitalists Unit, Department of Internal Medicine, Clínica Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.

Magazine: PloS One

Date: Jun 29, 2015

Internal Medicine [SP]

BACKGROUND:
Application of illness-severity scores in Intermediate Care Units (ImCU) shows conflicting results. The aim of the study is to design a severity-of-illness score for patients admitted to an ImCU.

METHODS:
We performed a retrospective observational study in a single academic medical centre in Pamplona, Spain. Demographics, past medical history, reasons for admission, physiological parameters at admission and during the first 24 hours of ImCU stay, laboratory variables and survival to hospital discharge were recorded. Logistic regression analysis was performed to identify variables for mortality prediction.

RESULTS:
A total of 743 patients were included. The final multivariable model (derivation cohort = 554 patients) contained only 9 variables obtained at admission to the ImCU: previous length of stay 7 days (6 points), health-care related infection (11), metastatic cancer (9), immunosuppressive therapy (6), Glasgow comma scale 12 (10), need of non-invasive ventilation (14), platelets 50000/mcL (9), urea 0.6 g/L (10) and bilirubin 4 mg/dL (9). The ImCU severity score (ImCUSS) is generated by summing the individual point values, and the formula for determining the expected in-hospital mortality risk is: eImCUSS points*0.099 - 4,111 / (1 + eImCUSS points*0.099 - 4,111). The model showed adequate calibration and discrimination. Performance of ImCUSS (validation cohort = 189 patients) was comparable to that of SAPS II and 3. Hosmer-Lemeshow goodness-of-fit C test was χ2 8.078 (p=0.326) and the area under receiver operating curve 0.802.

CONCLUSIONS:
ImCUSS, specially designed for intermediate care, is based on easy to obtain variables at admission to ImCU. Additionally, it shows a notable performance in terms of calibration and mortality discrimination.

CITATION  PLoS One. 2015 Jun 29;10(6):e0130989. doi: 10.1371/journal.pone.0130989.

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