Scientific publications

Allergic rhinitis causes loss of smell in children: The OLFAPEDRIAL study

Langdon C (1,2), Guilemany JM (1,2), Valls M (1), Alobid I (1,2), Bartra J (3,4), Dávila I (5), Del Cuvillo A (6), Ferrer M (7,4), Jáuregui I (8), Montoro J (9), Sastre J (10), Valero A (3,2), Mullol J (11,12).
(1) Unitat de Rinologia i Clínica de l'Olfacte, Servei d'Otorinolaringologia, Hospital Clínic, IDIBAPS, Barcelona, Catalonia, Spain.
(2) Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES). Barcelona.
(3) Unitat d'Al.lèrgia, Servei de Pneumologia i Al.lèrgia Respiratòria, Hospital Clínic. IDIBAPS. Universitat de Barcelona, Barcelona, Catalonia, Spain.
(4) Red de Investigación de Reacciones Adversas a Alergenos y Fármacos, RIRAAF, Spain.
(5) Servicio de Inmunoalergia, Complejo Asistencial Universitario de Salamanca. IBSAL, Salamanca, Spain.
(6) Unidad de Rinitis y Asma. UGC ORL. Hospital de Jerez, Cádiz, Spain.
(7) Departamento de Alergología e Inmunología Clínica, Clínica Universidad de Navarra Navarra, Pamplona, Spain.
(8) Servicio de Alergología, Hospital de Basurto, Bilbao, Spain.
(9) Hospital Universitario Arnau de Vilanova. Facultad de Medicina, Universidad Católica de Valencia "San Vicente Mártir", Valencia, Spain.
(10) Servicio de Alergia, Fundación Jiménez Díaz, Madrid, Spain.
(11) Unitat de Rinologia i Clínica de l'Olfacte, Servei d'Otorinolaringologia, Hospital Clínic, IDIBAPS, Barcelona, Catalonia, Spain.
(12) Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES). Barcelona 

Magazine: Pediatric Allergy and Immunology

Date: Sep 9, 2016

Allergology and Immunology Department

BACKGROUND:
The objective of the OLFAPEDRIAL study was to assess the olfactory dysfunction in allergic paediatric population, which has been scarcely studied.

METHODS:
Observational, cross-sectional, and multicentre study evaluated the sense of smell in untreated allergic rhinitis (AR) paediatric patients aged 6-12 yrs.

RESULTS:
Fourty-four percent (551 out of 1260) of children with AR reported smell dysfunction, with both loss of smell frequency (52.1%, p<0.001) and intensity (0.75±0.84, p<0.0001) being more frequent in patients with persistent than intermittent AR (38.0% and 0.51±0.73, respectively).

In addition, both loss of smell frequency and intensity increased according to disease severity (m-ARIA classification) but always being significantly higher in persistent (p<0.0001) than in intermittent AR.

CONCLUSIONS:
Children with allergic rhinitis present a mild-moderate loss of smell which frequency and intensity is clearly related to the disease duration and severity. The loss of smell can be considered, as in adults, a clinical marker of disease severity.

CITATION  Pediatr Allergy Immunol. 2016 Sep 9. doi: 10.1111/pai.12655

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