Scientific publications 

The Human Parahippocampal Region: I. Temporal Pole Cytoarchitectonic and MRI Correlation

Blaizot X, Mansilla F, Insausti AM, Constans JM, Salinas-Alamán A [SP], Pró-Sistiaga P, Mohedano-Moriano A, Insausti R.
Department of Health Sciences, School of Medicine, University of Castilla-La Mancha, 02006 Albacete, Spain.

Magazine: Cerebral Cortex

Date: Jan 11, 2010

Ophthalmology [SP]

The temporal pole (TP) is the rostralmost portion of the human temporal lobe. Characteristically, it is only present in human and nonhuman primates.

TP has been implicated in different cognitive functions such as emotion, attention, behavior, and memory, based on functional studies performed in healthy controls and patients with neurodegenerative diseases through its anatomical connections (amygdala, pulvinar, orbitofrontal cortex). TP was originally described as a single uniform area by Brodmann area 38, and von Economo (area TG of von Economo and Koskinas), and little information on its cytoarchitectonics is known in humans.

We hypothesize that 1) TP is not a homogenous area and we aim first at fixating the precise extent and limits of temporopolar cortex (TPC) with adjacent fields and 2) its structure can be correlated with structural magnetic resonance images. We describe here the macroscopic characteristics and cytoarchitecture as two subfields, a medial and a lateral area, that constitute TPC also noticeable in 2D and 3D reconstructions.

Our findings suggest that the human TP is a heterogeneous region formed exclusively by TPC for about 7 mm of the temporal tip, and that becomes progressively restricted to the medial and ventral sides of the TP. This cortical area presents topographical and structural features in common with nonhuman primates, which suggests an evolutionary development in human species.

CITATION  Cereb Cortex. 2010 Sep;20(9):2198-212

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