Scientific publications

Subacute cutaneous lupus erythematosus clinical, histopathological and immunophenotypical study of five cases

Vázquez-Doval J, Ruiz de Erenchun F, Contreras F, Soto de Delás J, Quintanilla E.
Department of Dermatology, University of Navarra, Pamplona, Spain

Magazine: Journal of Investigational Allergology and Clinical Immunology

Date: Jan 1, 1992

Dermatology Immunology [SP]

Subacute cutaneous lupus erythematosus (SCLE) is a recently described distinct subset of lupus erythematosus (LE) having characteristic clinical, serological and genetic features. The clinicopathological and serological findings of 5 patients are reported.

From a clinical point of view, we describe two types of cutaneous lesions: psoriasiform and annular pattern. ANA were present in 80% of the cases, anti-Ro was present in 60%, and anti-La in 20%; anti-RNP was positive in 1 patient. Circulating immune complexes were detected in 2 patients, and low levels of complement factors (C3, C4) in another 2 patients. The B- cell alloantigens HLA-A2, HLA-Bw4 or HLA-DR3 were present in 60% of the cases. The cutaneous histopathology revealed important changes in the epidermis.

Our findings are similar to those described by most other authors. Also, we would like to emphasize the low disease activity and benign course of our patients.

CITATION  J Investig Allergol Clin Immunol. 1992 Jan-Feb;2(1):27-32

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