Scientific publications

Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes

Richardson PG (1), Harvey RD (2), Laubach JP (1), Moreau P (3), Lonial S (2), San-Miguel JF (4).
(1a) Dana-Farber Cancer Institute , Harvard Medical School , Boston , MA , USA.
(2b) Winship Cancer Institute , Emory University , Atlanta , GA , USA.
(3c) Hematology Department , University Hospital , Nantes , France.
(4d) CIMA, IDISNA , Clínica Universidad de Navarra , Pamplona , Spain. 

Magazine: Expert Review of Clinical Pharmacology

Date: Jan 1, 2016

Haematology and Hameotherapy

ABSTRACT

Recently, outcomes for patients with multiple myeloma have improved dramatically due to improved and innovative therapies. However, most patients will either relapse or become refractory to current therapy.

Thus, a significant unmet need remains for novel agents to treat this patient population. Panobinostat, a potent pan-deacetylase inhibitor with a unique mechanism of action targeting both epigenetic regulation of gene expression and protein metabolism, has preclinical synergy with a number of agents, including the proteasome inhibitor bortezomib.

In a phase 3 trial of panobinostat with bortezomib and dexamethasone, addition of panobinostat significantly prolonged the median progression-free survival of patients with relapsed or relapsed and refractory multiple myeloma.

This review focuses on clinical development of panobinostat, with particular emphasis on pharmacokinetics and adverse event management.

CITATION  Expert Rev Clin Pharmacol. 2016;9(1):35-48. doi: 10.1586/17512433.2016.1096773. Epub 2015 Oct 26.

you maybe interested

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra