Number of beta-receptors in patients allergic to Dermatophagoides pteronyssinus
Gamboa PM, Sanz ML [SP], de la Cuesta CG, García BE, Castillo JG, Oehling A.
Departamento de Alergología e Inmunología Clínica, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
Magazine: Journal Investigational Allergology and Clinical Immunology
Date: Feb 1, 1991Allergology and Immunology Department
This study was carried out on 96 atopic patients with monosensitization against Dermatophagoides pteronyssinus and 30 control individuals.
The patients were divided into 3 subgroups: 27 asymptomatic patients, 27 patients who only presented nasal symptomatology, and 27 patients with marked bronchial symptomatology. Total serum IgE, antigen-specific histamine release, and the number of beta 2-adrenergic receptors in peripheral blood lymphocytes in all patients were determined. The control group presented the highest number of beta-receptors in comparison with the bronchial symptomatic and nasal symptomatic patients. However, asymptomatic patients presented numbers of beta-receptors similar to controls, with no significant differences between both groups. No significant correlation was found between beta-adrenergic receptors and levels of total serum IgE.
On the other hand, correlation between beta-receptors and specific histamine release was detected only in symptomatic nasal patients. It can be postulated that the decrease in beta-receptors is a consequence, and not the cause, of atopy.
CITATION J Investig Allergol Clin Immunol. 1991 Feb;1(1):59-67
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