Scientific publications

Development of Laser-Induced Choroidal Neovascularization in Rats after Retinal Damage by Sodium Iodate Injection

García-Layana A [SP], Vásquez G, Salinas-Alamán A [SP], Moreno-Montañés J [SP], Recalde S, Fernández-Robredo P.
Department of Ophthalmology, University Clinic, University of Navarra, Pamplona, Spain.

Magazine: Ophthalmic Research

Date: Aug 11, 2009

Ophthalmology [SP]

Purpose
To determine the role of the retinal pigment epithelium (RPE) in the development of laser-induced choroidal neovascularization (CNV) by selective damage with sodium iodate (SI).

Methods
In group 1, diode laser photocoagulation was applied to the right eye of Long-Evans rats (n = 11). In group 2 (n = 11), SI was administered intravenously at a dose of 40 mg/kg of body weight 2 days after photocoagulation. In group 3 (n = 10), SI was injected 2 days before laser was applied. In group 4 (n = 10), SI was injected immediately after photocoagulation. Results: CNV ingrowth developed in 42 of 93 burns (45%) of the laser group and in 46 of 75 burns (61%) when SI was administered 2 days after laser (p = 0.036). No CNV developed in the other groups.

Conclusions
The angiogenic effect of the RPE is essential during the first hours after the onset of the laser-induced CNV process. When the RPE was damaged before or at the time of photocoagulation, CNV was not induced. These results suggest that RPE integrity is a decisive element in CNV formation.

CITATION  Ophthalmic Res. 2009;42(4):205-12

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