Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor
Lorenzo-Betancor O, García-Martín E, Cervantes S, Agúndez JA, Jiménez-Jiménez FJ, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P.
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz RIRAAF/RETICS, Redes Temáticas de Investigación Cooperativa en Salud, Instituto de Salud Carlos III, Spain Department of Pharmacology, Medical School, University of Extremadura, Badajoz Department of Medicine-Neurology, Hospital ''Príncipe de Asturias'', Universidad de Alcalá, Madrid Department of Neurology, Hospital del Sureste, Arganda del Rey, Madrid Department of Neurology, Hospital La Mancha-Centro de Alcázar de San Juan, Ciudad Real Service of Neurology, Hospital La Princesa, University Hospital, Madrid Clinic for Nervous System Disorders and Service of Neurology, Hospital Universitario Son Dureta, Palma de Mallorca CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain
Magazine: European Journal of Neurology
Date: Nov 18, 2010Neurology [SP]
Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome-wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET.
We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.
We were unable to replicate the association between LINGO1 variants and familial ET.
Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.
CITATION Eur J Neurol. 2010 Nov 18. doi: 10.1111/j.1468-331.2010.03251
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