Scientific publications

Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects

Páramo J.A., Beloqui O., Colina I [SP]., Díez J., Orbe J.
Atherosclerosis Research, University Clinical, School of Medicine, University of Navarra, Pamplona, Spain

Magazine: Journal of Thrombosis and Haemostasis

Date: Apr 1, 2005

Medical Check-Ups Cardiology Haematology and Hameotherapy

Von Willebrand factor (VWF) is considered a reliable marker of endothelial damage. Plasma levels of VWF were measured in 857 middle-aged subjects (80.4% men) free of clinically overt atherosclerotic disease, in relation to cardiovascular risk factors, carotid intima-media thickness (IMT) and microalbuminuria, two established surrogate markers of atherosclerosis.

There was linear trend for the increase of VWF, carotid IMT (p < 0.001) and microalbuminuria (p = 0.018). The association between VEF and both markers remained statistically significant after adjusting for cardiovascular risk factors and inflammatory markers (p < 0.01).

In conclusion, VWF was independently associated with both structural and functional surrogates of atherosclerosis in asymptomatic subjects, thus representing a systemic biomarker of subclinical atherosclerosis.

CITATION J Thromb Haemost. 2007 Jan;5(1):91-7

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