Scientific publications

In situ hybridization of GAD mRNA in monkey and human brain: quantification at both regional and cellular levels

Herrero MT, Ruberg M, Hirsch EC, Mouatt A, Tobin AJ, Agid Y, Obeso JA, Javoy-Agid F.
INSERM U289, Hôpital de la Salpêtrière, Paris, France

Magazine: Neuroscience Letters

Date: Jul 9, 1993

Neurology [SP]

GAD mRNA was detected in human and monkey brain postmortem by in situ hybridization with an [35S]-labelled copy RNA corresponding to a 2.7-kb fragment of the coding region of human GAD mRNA. A characteristic and reproducible pattern of hybridization was obtained with the anti-sense, but not the sense probe in both monkey and human brain.

Microscopic examination of tissue sections showed that only neuronal perikarya, not glial cells, were labelled. The data confirm the heterogeneity of GAD mRNA distribution reported in rodent brain and non-human primate brain.

CITATION Neurosci Lett. 1993 Jul 9;157(1):57-61

you maybe interested

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra