Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways
Frühbeck G. [SP], Catalán V. [SP], Gómez-Ambrosi J. [SP], Rodríguez A.
Department of Endocrinology, Clínica Universitaria and Metabolic Research Laboratory, University of Navarra, c/Irunlarrea 1, 31008 Pamplona, Spain.
Magazine: Trends in Pharmacological Sciences
Date: Jul 1, 2006Obesity Unit Endocrinology and Nutrition [SP]
Advances in determining the mechanisms that underlie the control of energy balance in mammals have recently been provided by the discovery and characterization of aquaporin-7 (AQP7), a water-glycerol transporter that is present in the plasma membrane of fat-storing cells (adipocytes).
Recent studies have shown that the absence of AQP7 expression in fat cells increases glycerol kinase activity, boosting triacylglycerol synthesis and ultimately leading to obesity. Thus, AQP7 operates as a glycerol channel in vivo, whereby adipocyte glycerol permeability has a key role in the regulation of fat accumulation.
CITATION Trends Pharmacol Sci. 2006 Jul;27(7):345-7
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