Scientific publications

A pilot study of thymus extract in chronic non-A, non-B hepatitis.

Civeira MP [SP], Castilla A, Morte S, Serrano M, Prieto J.
Department of Internal Medicine, Clinica Universitaria, University of Navarra, Pamplona, Spain.

Magazine: Alimentary Pharmacology and Therapeutics

Date: Aug 1, 1989

Hepatology

In previous studies it has been suggested that activation of cellular immunity may have a role in controlling the activity of chronic non-A, non-B liver disease. We conducted a pilot study of therapy with a bovine thymus extract for 6 weeks in 15 consecutive patients with chronic non-A, non-B hepatitis, most of them sporadic cases.

Treatment induced immunomodulation, and in five patients a significant but transient diminution in aminotransferase levels was observed associated with increments in several parameters of cellular immunity.

This suggests that a longer administration of this or other related compounds, or treatment with a more potent immunomodulating agent, might be effective in these patients.

CITATION  Aliment Pharmacol Ther. 1989 Aug;3(4):395-401

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