PUBLICAÇÕES científicas

Risk of unintentional injuries in children and adolescents with ADHD and the impact of ADHD medications

Ruiz-Goikoetxea M (1), Cortese S (2), Aznarez-Sanado M (3), Magallón S (4), Zallo NA (5), Luis EO (6), de Castro-Manglano P (7), Soutullo C (8), Arrondo G (9).

(1) Servicio de Urgencias Extrahospitalarias Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
(2) Center for Innovation in Mental Health, University of Southampton, Academic Unit of Psychology, Southampton, UK; Faculty of Medicine, Clinical and Experimental Sciences (CNS and Psychiatry), University of Southampton, Southampton, UK; Department of Child and Adolescent Psychiatry, NYU Langone Medical Center, New York, NY, USA.
(3) Facultad de Educación y Psicología, Universidad de Navarra, Pamplona, Spain.
(4) Facultad de Educación y Psicología, Universidad de Navarra, Pamplona, Spain.
(5) Servicio de Urgencias Extrahospitalarias Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
(6) Facultad de Educación y Psicología, Universidad de Navarra, Pamplona, Spain.
(7) Departamento de Psiquiatría y Psicología Médica, Unidad de Psiquiatría Infantil y Adolescente, Clínica Universidad de Navarra, Pamplona, Spain.
(8) Departamento de Psiquiatría y Psicología Médica, Unidad de Psiquiatría Infantil y Adolescente, Clínica Universidad de Navarra, Pamplona, Spain.
(9) Instituto Cultura y Sociedad (ICS), Grupo Mente-Cerebro, Universidad de Navarra, Pamplona, Spain

Revisão:Neuroscience and Biobehavioral Reviews

Data: 18/Nov/2017

Psiquiatria e Psicologia Clínica [ES]

RESUMO

A systematic review with meta-analyses was performed to: 1) quantify the association between ADHD and risk of unintentional physical injuries in children/adolescents ("risk analysis"); 2) assess the effect of ADHD medications on this risk ("medication analysis").

We searched 114 databases through June 2017. For the risk analysis, studies reporting sex-controlled odds ratios (ORs) or hazard ratios (HRs) estimating the association between ADHD and injuries were combined. Pooled ORs (28 studies, 4,055,620 individuals without and 350,938 with ADHD) and HRs (4 studies, 901,891 individuals without and 20,363 with ADHD) were 1.53 (95% CI=1.40,1.67) and 1.39 (95% CI=1.06,1.83), respectively.

For the medication analysis, we meta-analysed studies that avoided the confounding-by-indication bias [four studies with a self-controlled methodology and another comparing risk over time and groups (a "difference in differences" methodology)].

The pooled effect size was 0.879 (95% CI=0.838,0.922) (13,254 individuals with ADHD). ADHD is significantly associated with an increased risk of unintentional injuries and ADHD medications have a protective effect, at least in the short term, as indicated by self-controlled studies.

CITAÇÃO DO ARTIGO  Neurosci Biobehav Rev. 2017 Nov 18. pii: S0149-7634(17)30672-3. doi: 10.1016/j.neubiorev.2017.11.007

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra