PUBLICAÇÕES científicas

Karnofsky performance score in acute renal failure as a predictor of short-term survival

José Ramón Pérez Valdivieso (1), Maria Bes-Rastrollo (2), Pablo Monedero (1), Jokin de Irala (2) and Francisco Javier Lavilla (3)
(1) Department of Anaesthesia and Critical Care
(2) Department of Preventive Medicine and Public Health
(3) Renal Unit, University Hospital of Navarra, University of Navarra, Pamplona


Data: 1/Dez/2007

Nefrologia [ES] Anestesia e Cuidados Intensivos [ES]

Karnofsky Performance Scale Index (KPS) is a measure of functional status that allows patients to be classified according to their functional impairment. We aim to assess if the prior KPS may predict the risk of death among patients with acute renal failure (ARF).

A cohort of 668 consecutive patients who had been admitted in an university-affiliated hospital between June 2000 and June 2006, and had been diagnosed with ARF, were studied. Three hundred and eighty-six patients with ARF who matched at least one of the RIFLE (Risk, Injury, Failure, Loss and End stage) criteria on increased serum creatinine were included for subsequent analysis. The group was divided into four categories, according to different Karnofsky scores measured by a nephrologist (380, 70, 60 and 250). We used an adjusted logistic regression model to assess the relationship between the Karnofky score and mortality.

A significant risk of in-hospital mortality within 90 days was observed when the other groups were compared with the 380 Karnofsky group. Adjusted odds ratios were 8.87 (95% confidence interval (CI) 3.03–25.99), 6.78 (95% CI 2.61–17.58) and 2.83 (95% CI 1.04–7.68), for Karnofsky groups of 250, 60 and 70, respectively. An adjusted odds ratio of 1.75 (95% CI 1.37–2.23) was observed for every 10 point decrease in KPS score.

Functional status as indicated by the KPS is an independent predictor of death in this cohort of patients with ARF. Patients who presented lower scores had increased mortality rates.

CITAÇÃO DO ARTIGO  Nephrology (Carlton). 2007 Dec;12(6):533-8

talvezlhe interesse


A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra


Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra