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Publicaciones científicas

63 Publicaciones científicas disponibles

  • Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Non-Small Cell Lung Carcinoma Patients

    23 de julio de 2019 | Revista: Journal of Thoracic Oncology

    Conde E (1), Hernandez S (2), Martinez R (2), Angulo B (1), De Castro J (3), Collazo-Lorduy A (2), Jimenez B (2), Muriel A (4), Mate JL (5), Moran T (6), Aranda I (7), Massuti B (7), Rojo F (8), Domine M (9), Sansano I (10), Garcia F (11), Felip E (10), Mancheño N (12), Juan O (12), Sanz J (13), Gonzalez-Larriba JL (13), Atienza-Cuevas L (14), Arriola-Arellano E (14), Abdulkader I (15), Garcia-Gonzalez J (15), Camacho C (16), Rodriguez-Abreu D (16), Teixido C (17), Reguart N (17), Gonzalez-Piñeiro A (18), Lazaro-Quintela M (18), Lozano MD (19), Gurpide A (19), Gomez-Roman J (20), Lopez-Brea M (20), Pijuan L (21), Salido M (21), Arriola E (21), Company A (22), Insa A (22), Esteban-Rodriguez I (3), Saiz M (23), Azkona E (23), Alvarez R (24), Artal A (24), Plaza ML (25), Aguiar D (25), Enguita AB (26), Benito A (27), Paz-Ares L (28), Garrido P (29), Lopez-Rios F (30)

    (1) Hospital Universitario HM Sanchinarro-CIBERONC, Madrid. Spain.
    (2) Hospital Universitario HM Sanchinarro, Madrid. Spain.
    (3) Hospital Universitario La Paz, Madrid. Spain.
    (4) Hospital Universitario Ramon y Cajal, IRYCIS and CIBERESP, Madrid. Spain.
    (5) Hospital Universitari Germans Trias i Pujol, Badalona. Spain.
    (6) Instituto Catalan de Oncologia-Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Badalona-Apllied Research Group of Oncology (B-ARGO), Badalona. Spain.
    (7) Hospital General Universitario-ISABIAL, Alicante. Spain.
    (8) Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz-CIBERONC, Madrid. Spain.
    (9) Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz, Madrid. Spain.
    (10) Hospital Universitari Vall d'Hebron, Barcelona. Spain.
    (11) Hospital Quironsalud, Barcelona. Spain.
    (12) Hospital Universitario La Fe, Valencia. Spain.
    (13) Hospital Clinico Universitario San Carlos, Madrid. Spain.
    (14) Hospital Universitario Puerta del Mar, Cadiz. Spain.
    (15) Hospital Clinico Universitario de Santiago, Santiago De Compostela.
    Spain.
    (16) Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas De Gran Canaria. Spain.
    (17) Hospital Clinic, Barcelona. Spain.
    (18) Hospital Alvaro Cunqueiro, Vigo. Spain.
    (19) Clinica Universidad de Navarra, Pamplona. Spain.
    (20) Hospital Universitario Marques de Valdecilla, Santander. Spain.
    (21) Hospital del Mar, Barcelona. Spain.
    (22) Hospital Clinico Universitario, Valencia. Spain.
    (23) Hospital Universitario de Cruces, Baracaldo. Spain.
    (24) Hospital Universitario Miguel Servet, Zaragoza. Spain.
    (25) Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria. Spain.
    (26) Hospital Universitario 12 de Octubre, Madrid. Spain.
    (27) Hospital Universitario Ramon y Cajal, Madrid. Spain.
    (28) Hospital Universitario 12 de Octubre-CIBERONC, Madrid. Spain.
    (29) Hospital Universitario Ramon y Cajal-CIBERONC, Madrid. Spain.
    (30) Hospital Universitario HM Sanchinarro-CIBERONC, Madrid. Spain.


  • Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer

    6 de julio de 2019 | Revista: The Lancet. Respiratory Medicine

    Duruisseaux M (1), Martínez-Cardús A (2), Calleja-Cervantes ME (2), Moran S (2), Castro de Moura M (2), Davalos V (2), Piñeyro D (2), Sanchez-Cespedes M (2), Girard N (3), Brevet M (4), Giroux-Leprieur E (5), Dumenil C (6), Pradotto M (7), Bironzo P (7), Capelletto E (7), Novello S (7), Cortot A (8), Copin MC (9), Karachaliou N (10), Gonzalez-Cao M (11), Peralta S (12), Montuenga LM (13), Gil-Bazo I (14), Baraibar I (15), Lozano MD (16), Varela M (17), Ruffinelli JC (18), Palmero R (18), Nadal E (18), Moran T (19), Perez L (20), Ramos I (21), Xiao Q (22), Fernandez AF (23), Fraga MF (24), Gut M 25, Gut I (25), Teixidó C (26), Vilariño N (27), Prat A (27), Reguart N (27), Benito A (28), Garrido P (29), Barragan I (30), Emile JF (31), Rosell R (32), Brambilla E (33), Esteller M (34)

    (1) Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Department of Respiratory Medicine, Groupement Hospitalier Est, Hôpital Louis-Pradel, Hospices Civils de Lyon, Lyon, France.
    (2) Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
    (3) Department of Respiratory Medicine, Groupement Hospitalier Est, Hôpital Louis-Pradel, Hospices Civils de Lyon, Lyon, France.
    (4) Department of Pathology, Centre de biologie et pathologie Est, Institut de Cancérologie des Hospices Civils de Lyon, Université Lyon 1, Lyon, France.
    (5) Department of Respiratory Diseases and Thoracic Oncology, APHP-Hôpital Ambroise Pare, Boulogne-Billancourt, France; EA4340, UVSQ, University Paris-Saclay, Boulogne-Billancourt, France.
    (6) Department of Respiratory Diseases and Thoracic Oncology, APHP-Hôpital Ambroise Pare, Boulogne-Billancourt, France.
    (7) Department of Oncology, University of Turin, AOU San Luigi, Turin, Italy.
    (8) Thoracic Oncology Department, CHU Lille, University of Lille, Lille, France; UMR 8161-M3T-Mechanisms of Tumorigenesis and Targeted Therapies, CNRS, Institut Pasteur de Lille, University of Lille, Lille, France.
    (9) Department of Pathology, CHU Lille, University of Lille, Lille, France.
    (10) Medical Oncology Service, Institute of Oncology Rosell, University Hospital Sagrat Cor, QuironSalud Group, Barcelona, Spain.
    (11) Medical Oncology Service, Quirón Dexeus University Hospital, Barcelona, Catalonia, Spain.
    (12) Medical Oncology Service, University Hospital Sant Joan de Reus, Reus, Spain.
    (13) Program in Solid Tumors and Biomarkers, Center for Applied Medical Research, Pamplona, Spain; Navarra Health Research Institute, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cancer, Madrid, Spain.
    (14) Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain; Navarra Health Research Institute, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cancer, Madrid, Spain.
    (15) Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain; Navarra Health Research Institute, Pamplona, Spain.
    (16) Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain; Navarra Health Research Institute, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cancer, Madrid, Spain.
    (17) Pathology Department, University Hospital Bellvitge, Barcelona, Spain.
    (18) Medical Oncology Department, Catalan Institute of Oncology, Hospital Duran I Reynals, Barcelona, Spain.
    (19) Medical Oncology Department, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Barcelona, Spain.
    (20) Department of Pathology, Hospitales Universitarios Regional y Virgen de la Victoria, Institute of Biomedical Research in Malaga, University of Málaga, Málaga, Spain.
    (21) Medical Oncology Service, Hospitales Universitarios Regional y Virgen de la Victoria, Institute of Biomedical Research in Malaga, University of Málaga, Málaga, Spain.
    (22) Pharmacoepigenetics Group, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
    (23) Cancer Epigenetics Laboratory, Institute of Oncology of Asturias, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain; Fundación para la Investigación Biosanitaria de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.
    (24) Nanomaterials & Nanotechnology Research Center, Universidad de Oviedo, Oviedo, Spain.
    (25) CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
    (26) Pathology Department, Hospital Clinic, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain.
    (27) Medical Oncology Department, Hospital Clinic, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain.
    (28) Pathology Department, University Hospital Ramon y Cajal, Madrid, Spain.
    (29) Medical Oncology Service, University Hospital Ramon y Cajal, Madrid, Spain; Centro de Investigación Biomédica en Red de Cancer, Madrid, Spain.
    (30) Medical Oncology Service, Hospitales Universitarios Regional y Virgen de la Victoria, Institute of Biomedical Research in Malaga, University of Málaga, Málaga, Spain; Pharmacoepigenetics Group, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
    (31) Department of Pathology Department, APHP-Hôpital Ambroise Pare, Boulogne-Billancourt, France.
    (32) Catalan Institute of Oncology, Germans Trias i Pujol Health Sciences Institute and Hospital, Barcelona, Spain.
    (33) Centre Hospitalier Grenoble, INSERM U1219, University UGA, Grenoble, France.
    (34) Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cancer, Madrid, Spain; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, Spain; Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Spain.


  • Identification of mutations associated with acquired resistance to sunitinib in renal cell-cancer

    8 de marzo de 2019 | Revista: International Journal of Cancer

    Elgendy M (1,2), Fusco JP (3,4), Segura V (5), Lozano MD (4,6,7), Minucci S (1,8), Echeveste JI (4,6), Gurpide A (3,4), Andueza M (3,4), Melero I (4,7,9), Sanmamed MF (3,4), Ruiz MR (3,4), Calvo A (4,10), Pascual JI (4,11), Velis JM (4,11), Miñana B (4,11), Valle RD (4,12), Pio R (4,7,13), Agorreta J (4,7,13), Abengozar M (4,6), Colecchia M (14), Brich S (14), Renne SL (14), Guruceaga E (5), Patiño-García A (4,13,15), Perez-Gracia JL (3,4,7).

    (1) Department of Experimental Oncology, European Institute of Oncology (IEO), Milan, Italy.
    (2) Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria.
    (3) Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
    (4) Health Research Institute of Navarra (IDISNA), Pamplona, Spain.
    (5) IDISNA and Bioinformatics Unit, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Navarra, Spain.
    (6) Pathology Department, Clinica Universidad de Navarra, Pamplona, Spain.
    (7) Centro de Investigación Biomédica en Red de Cáncer (CIBERONC).
    (8) Department of Biosciences, University of Milan, Milan, Italy.
    (9) Department of Immunology, Center for Applied Medical Research (CIMA), Pamplona, Spain.
    (10) Department of Histology and Pathology, School of Medicine, University of Navarra, Pamplona, Navarra, Spain.
    (11) Department of Urology, Clinica Universidad de Navarra, Pamplona and Madrid, Spain.
    (12) Department of Neurosurgery, University Clinic of Navarra, Pamplona, Spain.
    (13) Program in Solid Tumors. Center for Applied Medical Research (CIMA), Pamplona, Spain.
    (14) Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
    (15) Department of Pediatrics and Clinical Genetics, Clinica Universidad de Navarra, Pamplona, Spain.


  • Metastatic tumors in the pancreas: the role of endoscopic ultrasound-guided fine-needle aspiration

    11 de febrero de 2019 | Revista: Revista Española de Enfermedades Digestivas

    Betés M (1), González Vázquez S (2), Bojórquez A (3), Lozano MD (4), Echeveste JI (4), García Albarrán L (5), Muñoz Navas M (6), Súbtil JC (7).

    (1) Digestivo, Clinica Universidad de Navarra, España.
    (2) Aparato Digestivo, Clínica Universidad de Navarra-Madrid, España.
    (3) Aparato Digestivo, Clinica Universidad de Navarra, España.
    (4) Anatomía Patológica, Clínica Universidad de Navarra.
    (5) Aparato Digestivo, Hospital Virgen de la Concha.
    (6) Servicio de Aparato Digestivo, Clínica Universidad de Navarra.
    (7) Aparato Digestivo, Clínica Universidad de Navarra.

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