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Omalizumab is effective in nonautoimmune urticaria
Ferrer M, Gamboa P, Sanz ML, Goikoetxea MJ, Cabrera-Freitag P, Javaloyes G, Berroa F, Kaplan AP.
We performed an open prospective observational study to assess whether omalizumab is effective treatment of patients with nonautoimmune chronic urticaria who are unresponsive to antihistamines, and in some instances, unresponsive to low-dose corticosteroid and/or cyclosporine.
We included the first 9 consecutive patients with severe nonautoimmune chronic urticaria who fulfilled the aforementioned criteria. The patients were designated “nonautoimmune” by measuring histamine release (1.22; interquartile range [IR] 0-9.9), and CD63 expression (0.62; IR 0-4.4) on incubation of patients’ sera with donor basophils, and all subjects were negative.
CITA DEL ARTÍCULO J Allergy Clin Immunol. 2011 May;127(5):1300-2. doi: 10.1016/j.jaci.2010.12.1085. Epub 2011 Feb 11.
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