Non-invasive diagnosis of rejection in heart transplant: usefulness of Doppler echocardiography

Cardiac transplantation is a valid therapeutic option for advanced chronic heart failure, with a one year survival of 60-80%. Although the introduction of cyclosporine has markedly improved survival in heart transplant recipients, early detection of cardiac allograft rejection remains the major problem to be solved.

At present, the diagnosis of cardiac rejection has been based on the results of endomyocardial biopsy, which remains actually as the gold standard for rejection surveillance. However, ideally the detection of cardiac rejection should be noninvasive to allow frequent follow-up of the patients. Several attempts have been made to find a noninvasive alternative to replace endomyocardial biopsy, doppler-echocardiography being the most promising technique.

A review of current noninvasive methods for graft rejection detection will be discussed emphasising the importance of doppler-echocardiography.

CITA DEL ARTÍCULO  Rev Med Univ Navarra. 1993 Jan-Mar;38(1):8-11