Different functional outcomes of intercellular membrane transfers to monocytes and T cells
HoWangYin KY, Alegre E, Daouya M, Favier B, Carosella ED, LeMaoult J.
CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475 Paris, France.
Revista: Cellular and Molecular Life Sciences
Fecha: 01/04/2010Bioquímica Clínica
Trogocytosis is the uptake of membranes from one cell by another. Trogocytosis has been demonstrated for monocytes, B cells, T cells, and NK cells. The acquisition of the tolerogenic molecule HLA-G by T cells and NK cells makes them behave as regulatory cells.
We investigated here whether HLA-G, which is expressed by tumor cells in vivo, could be acquired by monocytes and if this transfer could have functional consequences. We demonstrate that resting, and even more so, activated monocytes efficiently acquire membrane-bound HLA-G from HLA-G tumor cells by trogocytosis. However, we demonstrate that HLA-G quickly disappears from the surface of the monocytes in contrast to the HLA-G acquired by T cells.
Consequently, HLA-G(acq+) monocytes do not reliably inhibit the on-going proliferation of autologous activated T cells and do not inhibit their cytokine production. Thus, we show that the acquirer cell may control the functional outcome of trogocytosis.
CITA DEL ARTÍCULO Cell Mol Life Sci. 2010 Apr;67(7):1133-45.
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