Is regression of atherosclerotic plaque possible?
Páramo JA (1), Civeira F (2). (1) Servicio de Hematología, Laboratorio de Aterotrombosis, Clínica Universidad de Navarra, Pamplona, España.
(2) Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Servicio de Medicina Interna, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, España.
Magazine: Clínica e Investigación en Arteriosclerosis
Date: Sep 27, 2016Hematología y Hemoterapia [SP]
As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes
Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies.
The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion ('angiographic paradox').
A number of imaging modalities (vascular ultrasound and virtual histology, MRI, optical coherence tomography, positron tomography, etc.) are used for non-invasive assessment of atherosclerosis; most of them can identify plaque volume and composition beyond lumen stenosis.
An 'aggressive' lipid-lowering strategy is able to reduce the plaque burden and the incidence of cardiovascular events; this may be attributable, at least in part, to plaque-stabilizing effects.
CITATION Clin Investig Arterioscler. 2016 Sep 27. pii: S0214-9168(16)30057-2. doi: 10.1016/j.arteri.2016.05.003
you mayBE INTERESTED
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.