Scientific publications
FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes
Gema Frühbeck 1 2 3 4 , Victoria Catalán 1 2 3 , Víctor Valentí 2 3 5 , Rafael Moncada 2 3 6 , Javier Gómez-Ambrosi 1 2 3 , Sara Becerril 1 2 3 , Camilo Silva 2 3 4 , Piero Portincasa 7 , Javier Escalada 2 3 4 , Amaia Rodríguez 8 9 10
A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death [1, 2]. Excessive adipose tissue (AT) might contribute to more extensive viral spread with increased shedding, immune activation, and cytokine amplification [3].
Several factors secreted by contracting muscle, termed myokines, mediate the beneficial effects of exercise in a wide range of diseases, including obesity [4].
Thus, we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family, FNDC4 and FNDC5, in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.
CITATION Cell Mol Immunol. 2021 Oct;18(10):2457-2459. doi: 10.1038/s41423-021-00762-0
Our authors
