PUBLICAÇÕES científicas

The impact of silent vascular brain burden in cognitive impairment in Parkinson's disease

González-Redondo R, Toledo J, Clavero P, Lamet I, García-García D, García-Eulate R [ES], Martínez-Lage P, Rodríguez-Oroz MC.
Clínica Universidad de Navarra, Pamplona Neuroscience Area, CIMA, Pamplona Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Centro de Investigación y Terapias Avanzadas, Fundación CITA-Alzheimer, San Sebastian, Spain.

Revisão:European Journal of Neurology

Data: 23/Fev/2012

Neurologia [ES]

Background and purpose
White matter hyperintensities (WMHs) detected by magnetic resonance imaging (MRI) of the brain are associated with dementia and cognitive impairment in the general population and in Alzheimer's disease. Their effect in cognitive decline and dementia associated with Parkinson's disease (PD) is still unclear.

Methods
We studied the relationship between WMHs and cognitive state in 111 patients with PD classified as cognitively normal (n=39), with a mild cognitive impairment (MCI) (n=46) or dementia (n=26), in a cross-sectional and follow-up study. Cognitive state was evaluated with a comprehensive neuropsychological battery, and WMHs were identified in FLAIR and T2-weighted MRI. The burden of WMHs was rated using the Scheltens scale.

Results
No differences in WMHs were found between the three groups in the cross-sectional study. A negative correlation was observed between semantic fluency and the subscore for WMHs in the frontal lobe. Of the 36 non-demented patients re-evaluated after a mean follow-up of 30 months, three patients converted into MCI and 5 into dementia. Progression of periventricular WMHs was associated with an increased conversion to dementia. A marginal association between the increase in total WMHs burden and worsening in the Mini Mental State Examination was encountered.

Conclusions
White matter hyperintensities do not influence the cognitive status of patients with PD. Frontal WMHs have a negative impact on semantic fluency. Brain vascular burden may have an effect on cognitive impairment in patients with PD as WMHs increase overtime might increase the risk of conversion to dementia. This finding needs further confirmation in larger prospective studies.

CITAÇÃO DO ARTIGO  Eur J Neurol. 2012 Feb 23. doi: 10.1111/j.1468-1331.2012.03682.x.

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra