Publicações científicas

Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model

Obeso J.A., Rodríguez-Oroz M.C., Rodríguez M., DeLong M.R., Olanow C.W.
Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, University of Navarra, Pamplona, Spain

Revisão:Annals of Neurology

Data: 1/Abr/2000

Neurologia [ES]

The anatomical and physiological basis of levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD) is reviewed in the light of the current model for the organization of the basal ganglia.

This model, which was developed in the late 1980s, works relatively well in explaining the motor features of PD but, for example, it does not account for why tremor, rigidity, bradykinesia, gait dysfunction and postural instability present to differing degrees in different patients, and may respond differently to levodopa treatment or surgical procedures. Recent information suggests that LIDs develop as a consequence of pulsatile stimulation of dopamine receptors, with consequent dysregulation of genes and proteins in downstream neurons resulting in changes in neuronal firing patterns.

A modified model of the basal ganglia in PD patients with LID is proposed, which incorporates more recent clinical and experimental data.

CITAÇÃO DO ARTIGO  Ann Neurol. 2000 Apr;47(4 Suppl 1):S22-32; discussion S32-4

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra