Publicações científicas

Panobinostat for the Treatment of Multiple Myeloma

Laubach JP(1), Moreau P (2), San-Miguel JF (3), Richardson PG (4).
(1) Medical Oncology, Dana Farber Cancer Institute.
(2) University hospital hôtel-dieu, Hematology Department, University Hospital Hôtel-Dieu, Place Alexis Ricordeau, 44093 Nantes cedex 01, France.
(3) Clinical & Translational Medicine, Clínica Universidad de Navarra.
(4) Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute.

Revisão:Clinical Cancer Research

Data: 11/Set/2015

Hematologia e Hemoterapia

RESUMEN

Panobinostat is a potent oral deacetylase inhibitor that alters gene expression through epigenetic mechanisms and inhibits protein degradation.

It was recently approved by the US Food and Drug Administration for use in combination with bortezomib and dexamethasone in patients with relapsed multiple myeloma who have received ≥ 2 prior regimens, including bortezomib and an immunomodulatory drug.

Panobinostat was approved based on results from the phase 3 PANORAMA 1 trial in patients with relapsed or relapsed and refractory multiple myeloma, which showed that panobinostat plus bortezomib and dexamethasone significantly extended progression-free survival (median, 12.0 months) compared with placebo plus bortezomib and dexamethasone (median, 8.1 months; P < .0001).

Additional ongoing trials are evaluating panobinostat in combination with other partners in the relapsed/refractory and newly diagnosed treatment settings. This review focuses on panobinostat and its mechanism of action, pharmacokinetics, and clinical data in the treatment of relapsed or relapsed and refractory multiple myeloma.

CITAÇÃO DO ARTIGO  Clin Cancer Res. 2015 Sep 11. pii: clincanres.0530.2015.

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra