PUBLICAÇÕES científicas

Membrane redistributions through multi-intercellular exchanges and serial trogocytosis

Alegre E [ES], Howangyin KY, Favier B, Baudhuin J, Lesport E, Daouya M, Gonzalez A [ES], Carosella ED, Lemaoult J.
Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain

Revisão:Cell Research

Data: 1/Set/2010

Bioquímica Clínica [ES]

RESUMO

Trogocytosis is a rapid transfer between cells of membranes and associated proteins. Trogocytic exchanges have been investigated between different cell types, mainly in two-cell systems, involving one donor and one acceptor cell type. Here, we studied trogocytosis in a more complex system, involving not only several immune cell subsets but also multiple tumor cells. We show that CD4(+) T cells, CD8(+) T cells and monocytes can acquire membrane patches and the intact proteins they contain from different tumor cells by multiple simultaneous trogocytoses. The trogocytic capabilities of CD4(+) and CD8(+) T cells were found to be similar, but inferior to that of autologous monocytes. Activated peripheral-blood mononuclear cells (PBMCs) may also exchange membranes between themselves in an all-autologous system.

For this reason, monocytes are capable of acquiring membranes from multiple tumor cell sources, and transfer them again to autologous T cells, along with some of their own membranes (serial trogocytosis). Our data illustrate the extent of membrane exchanges between autologous activated immune effector cells and their environment, and how the cellular content of the local environment, including bystander cells, may impact the functions of immune effector cells.

CITAÇÃO DO ARTIGO  Cell Res. 2010 Nov;20(11):1239-51. Epub 2010 Sep 28

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra