PUBLICAÇÕES científicas

Levodopa-induced dyskinesias in Parkinson's disease: clinical and pharmacological classification

Luquin M.R., Scipioni O., Vaamonde J., Gershanik O., Obeso J.A.
Department of Neurology, Clínica Universitaria, University of Navarra, Pamplona-Spain

Revisão:Movement Disorders

Data: 1/Jan/1992

Neurologia [ES]

Levodopa-induced dyskinesias (LID) in Parkinson's disease (PD) may be classified into three main categories: On dyskinesias, diphasic dyskinesias (DD), and off periods.

The study of 168 parkinsonian patients showed that about half (n = 84) showed one pattern of LID only. A combination of two was present in 68, and 16 had the three presentation patterns. A fairly good correlation between type of dyskinesia and presentation pattern was established. Chorea, myoclonus, and dystonic movements occurred during the on period. Dystonic postures, particularly affecting the feet, were mainly present in the off period, but a few patients had a diphasic presentation.

Repetitive stereotyped movements of the lower limbs always corresponded to DD. Acute pharmacological tests using dopamine agonists (subcutaneous apomorphine 3-8 mg; intravenous lisuride 0.1-0.15 mg) and dopamine antagonists (intravenous sulpiride 200-400 mg and intravenous chlorpromazine 25 mg) were performed in 40 patients. Dopamine agonists enhanced on dyskinesias and markedly reduced or abolished off period dystonia and DD. Dopamine antagonists reduced all types of LID but usually aggravated parkinsonism.

These clinical and pharmacological results indicate that LID in PD are a heterogeneous phenomenon difficult to explain on the basis of a single pathophysiological mechanism.

CITAÇÃO DO ARTIGO Mov Disord. 1992;7(2):117-24

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra