Publicações científicas

Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor

Lorenzo-Betancor O, García-Martín E, Cervantes S, Agúndez JA, Jiménez-Jiménez FJ, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P.
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz RIRAAF/RETICS, Redes Temáticas de Investigación Cooperativa en Salud, Instituto de Salud Carlos III, Spain Department of Pharmacology, Medical School, University of Extremadura, Badajoz Department of Medicine-Neurology, Hospital ''Príncipe de Asturias'', Universidad de Alcalá, Madrid Department of Neurology, Hospital del Sureste, Arganda del Rey, Madrid Department of Neurology, Hospital La Mancha-Centro de Alcázar de San Juan, Ciudad Real Service of Neurology, Hospital La Princesa, University Hospital, Madrid Clinic for Nervous System Disorders and Service of Neurology, Hospital Universitario Son Dureta, Palma de Mallorca CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain

Revisão:European Journal of Neurology

Data: 18/Nov/2010

Neurologia [ES]

Background
Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome-wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET.

Methods
We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.

Results
We were unable to replicate the association between LINGO1 variants and familial ET.

Conclusions
Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.

CITAÇÃO DO ARTIGO Eur J Neurol. 2010 Nov 18. doi: 10.1111/j.1468-331.2010.03251

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra