Publicações científicas

IOTA simple rules for discriminating between benign and malignant adnexal masses: a prospective external validation

Alcázar JL [ES], Pascual MA, Olartecoechea B [ES], Graupera B, Aubá M [ES], Ajossa S, Hereter L, Julve R, Gastón B, Peddes C, Sedda F, Piras A, Saba L, Guerriero S.
Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain

Revisão:Ultrasound in Obstetrics & Ginecology

Data: 10/Abr/2013

Ginecologia e Obstetrícia

OBJECTIVE
To determine the diagnostic performance of simple rules for discriminating between benign and malignant adnexal masses.

METHODS
A prospective study was performed between January 2011 and June 2012. Eligible patients were all women diagnosed as having a persistent adnexal mass. Four trainees evaluated the adnexal mass by transvaginal ultrasound under the supervision of an expert examiner. The trainee had to analyze the mass according to IOTA simple rules providing a diagnosis of malignant, benign or inconclusive. All women ultimately included underwent surgery and tumor removal in the center of recruitment. Diagnostic performance was assessed by calculating the sensitivity and specificity as well as positive (LR+) and negative (LR-) likelihood ratios.

RESULTS
340 women were included (patients' mean age: 42.1 years, range: 13 to 79). Fifty-five (16.2%) tumors were malignant and 285 (83.8%) were benign. Simple rules could be applied in 270 (79.4%). Sensitivity, specificity, LR+ and LR- in those 270 cases in which the rules could be applied were 87.9% (95%CI 72.4% to 95.2%), 97.5% (95%CI 94.6% to 98.8%), 34.7 (95%CI 15.6 to 77.3) and 0.12 (95%CI 0.05 to 0.31), respectively.

CONCLUSIONS
Simple rules perform acceptably well in terms of specificity in hands of non-expert examiners. However, non-experts examiners had a 12% false-negative rate, which is relatively high.

CITAÇÃO DO ARTIGO 2013 Apr 10. doi: 10.1002/uog.12485

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