Publicações científicas

Epicardial Adipose Tissue in the General Middle-aged Population and Its Association With Metabolic Syndrome

Calabuig Á (1), Barba J (2), Guembe MJ (3), Díez J (4), Berjón J (5), Martínez-Vila E (6), Irimia P (6), Toledo E (7).
(1) Departamento de Cardiología y Cirugía Cardiovascular, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Navarra, Spain.
(2) Departamento de Cardiología y Cirugía Cardiovascular, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain.
(3) Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Servicio de Planificación, Evaluación y Gestión del Conocimiento, Sección de Formación, Departamento de Salud, Gobierno de Navarra, Pamplona, Navarra, Spain.
(4) Departamento de Cardiología y Cirugía Cardiovascular, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Navarra, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Programa de Enfermedades Cardiovasculares, Centro de Investigación Médica Aplicada, Universidad de Navarra, Pamplona, Navarra, Spain.
(5) Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Servicio de Cardiología, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain.
(6) Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Departamento de Neurología, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, Navarra, Spain.
(7) Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Departamento de Medicina Preventiva y Salud Pública, Universidad de Navarra, Pamplona, Navarra, Spain; Centro de Investigación Biomédica en Red (CIBER) - Fisiopatología de la Obesidad y Nutrición, Madrid, Spain. 

Revisão:Revista Española de Cardiología

Data: 22/Nov/2016

Neurologia [ES] Cardiología

INTRODUCTION AND OBJECTIVES:
There is currently increasing interest in epicardial adipose tissue (EAT) as a marker of cardiovascular disease. Our purpose was to describe EAT, measured by transthoracic echocardiography, and to assess its association with metabolic syndrome (MS) in the RIVANA population-based study.

METHODS:
Physical examination was performed in 880 participants aged 45 to 74 years (492 of them with MS according to the harmonized definition). Fasting glucose, high-density lipoprotein cholesterol, triglyceride, and C-reactive protein concentrations were determined in a blood sample. In all participants, EAT thickness was measured with transthoracic echocardiography at end-systole.

RESULTS:
Among participants without MS, the prevalence of EAT ≥ 5mm significantly increased with age (OR > 65 years vs 45-54 years=8.22; 95%CI, 3.90-17.35; P for trend<.001). Increasing EAT quintiles were significantly associated with MS (OR fifth quintile vs first quintile=3.26; 95%CI, 1.59-6.71; P for trend=.001).

Considering the different MS criteria, increasing quintiles of EAT were independently associated with low high-density lipoprotein cholesterol (OR fifth quintile vs first quintile=2.65; 95%CI, 1.16-6.05; P for trend=.028), high triglycerides (OR fifth quintile vs first quintile=2.22; 95%CI, 1.26-3.90; P for trend=.003), and elevated waist circumference (OR fifth quintile vs first quintile=6.85; 95%CI, 2.91-16.11; P for trend<.001).

CONCLUSIONS:
In a subsample of the general population, EAT measured by echocardiography increased significantly and independently with age. Increased EAT thickness was independently associated with MS and with low high-density lipoprotein cholesterol, high triglycerides, and elevated waist circumference as individual criteria.

CITAÇÃO DO ARTIGO  Rev Esp Cardiol (Engl Ed). 2016 Nov 22. pii: S1885-5857(16)30216-X. doi: 10.1016/j.rec.2016.08.001

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