Publicações científicas

Effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections

Jose L. Del Pozo [ES] (a,b), Marta Alonso (b), Alicia Serrera (b), Silvia Hernaez (b), Aitziber Aguinaga (b) and Jose Leiva [ES] (b)
(a) Division of Infectious Diseases, Clínica Universitaria de Navarra, Pamplona, Spain
(b) Department of Clinical Microbiology, Clínica Universitaria de Navarra, Pamplona, Spain

Revisão:Diagnostic Microbiology and Infectious Disease

Data: 1/Jan/2009

Microbiologia Clínica [ES] Doenças Infecciosas [ES]

OBJECTIVE
The purpose of this study is to evaluate the efficacy of antibiotic lock therapy to treat port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections.

PATIENTS AND METHODS
We conducted a prospective observational study including all patients with port-related bacteremia diagnosed at the Clinica Universitaria de Navarra, Pamplona, Spain. During a 36-month period, 110 patients were diagnosed with port-related bacteremia. Of these patients, 18 met criteria to be enrolled in the study. They were treated with a combination of systemic and antibiotic lock therapy (12-24 h/day during 7-14 days). Treatment effectiveness was assessed by clinical and microbiologic criteria.

RESULTS
Treatment was associated with clinical and microbiologic success in 88.8% of our patients (2/2 of the Propionibacterium acnes, 5/5 of the Corynebacterium spp., 6/7 of the Gram-negative bacillus, and 3/4 of the Enterococcus faecium port-related bloodstream infections). Mean increase of port life span for all patients after bacteremia was 288 days (range, 0-1403 days).

CONCLUSION
Antibiotic lock therapy combined with systemic antibiotics appears to be a safe and effective treatment of port-related bacteremia caused by enterococci, Gram-negative, or Gram-positive bacilli if the patient is stable and no septic syndrome is associated.

CITAÇÃO DO ARTIGO  Diagn Microbiol Infect Dis. 2009 Feb;63(2):208-12

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