PUBLICAÇÕES científicas

Docetaxel administered during pregnancy for inflammatory breast carcinoma

Nieto Y., Santisteban M., Aramendía J.M. [ES], Fernández-Hidalgo O., García-Manero M., López G.
Department of Medical Oncology, University of Navarra, Pamplona, Spain.

Revisão:Clinical Breast Cancer

Data: 1/Fev/2006

Área do Cancro da Mama Oncologia Médica

We report the case of a 35-year-old pregnant woman with inflammatory breast carcinoma initially treated with 5-fluorouracil/doxorubicin/cyclophosphamide beginning her 13th week of pregnancy. There was no noticeable shrinkage of the axillary or breast tumors after 4 cycles, at which point the patient accepted a treatment change to docetaxel. Four cycles of docetaxel at 100 mg/m2 every 21 days were delivered from the 25th week of pregnancy with good tolerance.

She exhibited a clinical complete response, determined by clinical examination and imaging tests. Obstetric monitoring with fetal ultrasound showed normal fetal development throughout chemotherapy. After delivery of a healthy child, she underwent surgery, which showed tumor downstaging to pT0 N2, followed by radiation therapy and hormone therapy.

This report suggests the safety of docetaxel after the first trimester of pregnancy.

CITAÇÃO DO ARTIGO  Clin Breast Cancer. 2006 Feb;6(6):533-4

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