PUBLICAÇÕES científicas

Distribution of calbindin D-28k and parvalbumin neurons and fibers in the rat basal ganglia

Hontanilla B, Parent A, de las Heras S, Giménez-Amaya JM.
Departamento de Cirugía Plástica y Reparadora, Clínica Universitaria, Universidad de Navarra, Pamplona, Spain.

Revisão:Brain Research Bulletin

Data: 15/Set/1998

This review deals with the distribution of immunoreactivity for calbindin D-28k (CB) and parvalbumin (PV) in the different nuclei of the rodent basal ganglia analyzed with the data available after the use of single and double antigen procedures applied to single sections.

These findings reveal that CB and PV are distributed according to a highly heterogeneous pattern in the caudate putamen complex (CPu), globus pallidus (GP), entopeduncular nucleus (EP), subthalamic nucleus (STh) and substantia nigra (SN) of the rat.

In each basal ganglia structure, the two calcium-binding proteins label different neuronal subsets. Therefore, the use of CB and PV immunohistochemistry may be considered as an excellent tool to define distinct chemoarchitectonic and functional domains within the complex organization of the basal ganglia. Double immunohistochemical methods are also useful to illustrate the relationships between the different chemical subdivisions of the CPu, GP, EP, STh and SN and the chemically characterized connections with each other and with other forebrain and brainstem structures. However, specific rules should be followed when combining single and double immunostaining procedures, and the results of such studies must be evaluated with caution.

When they are used properly, these methods can reveal hitherto unknown principles of organization of the basal ganglia and thus shed new light on the anatomical and functional organization of this set of subcortical structures involved in the control of motor behavior.

CITAÇÃO DO ARTIGO  Brain Res Bull. 1998 Sep 15;47(2):107-16

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