Publicações científicas

Contribution of white matter lesions to gray matter atrophy in multiple sclerosis: evidence from voxel-based analysis of T1 lesions in the visual pathway.

Sepulcre J, Goñi J, Masdeu JC, Bejarano B, Vélez de Mendizábal N, Toledo JB, Villoslada P.
Departamento de Neurología, Clínica Universitaria de Navarra, Universidad de Navarra, Pío XII 36, 31008 Pamplona, Navarra, Spain.

Revisão:Archives of Neurology

Data: 1/Fev/2009

Neurologia [ES]

BACKGROUND
The biological basis of gray matter (GM) atrophy in multiple sclerosis is not well understood, but GM damage seems to be the most critical factor leading to permanent disability.

OBJECTIVE
To assess to what extent white matter (WM) lesions contribute to regional GM atrophy in multiple sclerosis. DESIGN: Because optic pathway GM atrophy and optic radiation lesions, rather than being related to each other, could be independent results of the disease, we applied a nonaprioristic WM method to analyze the interrelationships of both phenomena. On a voxel-by-voxel basis, we correlated T1 magnetic resonance imaging-derived lesion probability maps of the entire brain with atrophy of the lateral geniculate nuclei and calcarine/pericalcarine cortices.

SETTING
Multiple sclerosis center, University of Navarra, Pamplona, Spain.

PATIENTS
Sixty-one patients with multiple sclerosis.

MAIN OUTCOME MEASURE
Mapping of WM regions contributing to GM atrophy in the optic pathway.

RESULTS
Patients with multiple sclerosis had lateral geniculate nucleus atrophy, which correlated with the presence of lesions specifically in the optic radiations but not in the rest of the brain. Optic pathway lesions explained up to 28% of the change of variance in lateral geniculate nucleus atrophy. Patients also had occipital cortex atrophy, which did not correlate with lesions in the optic radiations or any other WM region.

CONCLUSIONS
Focal WM damage is associated with upstream GM atrophy, suggesting that retrograde damage of the perikarya from axonal injury in multiple sclerosis plaques is one of the significant factors in the genesis of GM atrophy, although other neurodegenerative processes are probably at work as well.

CITAÇÃO DO ARTIGO  Arch Neurol. 2009 Feb;66(2):173-9

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra