PUBLICAÇÕES científicas

Candida biofilm-related infections

Del Pozo JL [ES] (1), Cantón E (2).
(1) Área de Enfermedades Infecciosas y Microbiología Clínica, Laboratorio de Biofilms Microbianos, Clínica Universidad de Navarra, España; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, España.
(2) Unidad de Microbiología Experimental, Centro de Investigación La Fe, Valencia, España. 

Revisão:Revista Iberoamericana de Micología

Data: 17/Ago/2015

Microbiologia Clínica [ES] Doenças Infecciosas [ES]

RESUMO

The number of biomedical devices (intravascular catheters, heart valves, joint replacements, etc.) that are implanted in our hospitals has increased exponentially in recent years. Candida species are pathogens which are becoming more significant in these kinds of infections. Candida has two forms of development: planktonic and in biofilms.

A biofilm is a community of microorganisms which adhere to a surface and are enclosed by an extracellular matrix. This form of development confers a high resistance to the antimicrobial agents.

This is the reason why antibiotic treatments usually fail and biomedical devices may have to be removed in most cases. Unspecific adhesion mechanisms, the adhesion-receptor systems, and an intercellular communication system called quorum sensing play an essential role in the development of Candida biofilms.

In general, the azoles have poor activity against Candida biofilms, while echinocandins and polyenes show a greater activity. New therapeutic strategies need to be developed due to the high morbidity and mortality and high economic costs associated with these infections. Most studies to date have focused on bacterial biofilms.

The knowledge of the formation of Candida biofilms and their composition is essential to develop new preventive and therapeutic strategies.

CITAÇÃO DO ARTIGO  Rev Iberoam Micol. 2015 Aug 17. pii: S1130-1406(15)00057-1. doi: 10.1016/j.riam.2015.06.004

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra