Publicaciones científicas

The role of pulsatile versus continuous dopamine receptor stimulation for functional recovery in Parkinson's disease

Obeso JA, Grandas F, Herrero MT, Horowski R.
Movement Disorders Unit, Clínica Universitaria, University of Navarra, Pamplona, Spain.

Revista: The European Journal of Neuroscience

Fecha: 01-jun-1994


More effective measures to control and replace the dopaminergic deficit of Parkinson's disease are being actively sought.

One basic problem is how the striatal dopamine loss should be replaced in order to mimic most accurately the physiological state. Animal electrophysiology indicates that the dopaminergic nigrostriatal pathway has a dual tonic and phasic action. Intermittent dopaminergic stimulation is associated with behavioural hyposensitivity both in animal models and in patients with Parkinson's disease. Continuous dopaminergic stimulation provides a tonic background and improves some clinical problems but is also associated with tolerance. None of the available pharmacological approaches can restore the dopamine deficiency of Parkinson's disease to physiological levels.

Continuous dopaminergic stimulation for < 24 h, associated with small doses of levodopa or a short-acting dopamine agonist, appears to be the best, albeit imperfect, therapeutic approach until other, more efficacious remedies are developed.

CITA DEL ARTÍCULO  Eur J Neurosci. 1994 Jun 1;6(6):889-97



La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

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