Independent component analysis separates spikes of different origin in the EEG
Urrestarazu E., Iriarte J., Artieda J., Alegre M., Valencia M., Viteri C.
Clinical Neurophysiology Section, Foundation for Applied Medical Research, Department of Neurology, Clínica Universitaria/School of Medicine, University of Navarra, Pamplona, Spain
Revista: Journal of Clinical Neurophysiology
Fecha: 01-feb-2006Neurología Neurofisiología
Independent component analysis (ICA) is a novel system that finds independent sources in recorded signals. Its usefulness in separating epileptiform activity of different origin has not been determined. The goal of this study was to demonstrate that ICA is useful for separating different spikes using samples of EEG of patients with focal epilepsy. Digital EEG samples from four patients with focal epilepsy were included.
The patients had temporal (n = 2), centrotemporal (n = 1) or frontal spikes (n = 1). Twenty-six samples with two (or more) spikes from two different patients were created. The selection of the two spikes for each mixed EEG was performed randomly, trying to have all the different combinations and rejecting the mixture of two spikes from the same patient. Two different examiners studied the EEGs using ICA with JADE paradigm in Matlab platform, trying to separate and to identify the spikes.
They agreed in the correct separation of the spikes in 24 of the 26 samples, classifying the spikes as frontal, temporal or centrotemporal, left or right sided. The demonstration of the possibility of detecting different artificially mixed spikes confirms that ICA may be useful in separating spikes or other elements in real EEGs.
CITA DEL ARTÍCULO J Clin Neurophysiol. 2006 Feb;23(1):72-8
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