Publicaciones científicas

Heart regeneration after myocardial infarction using synthetic biomaterials

Pascual-Gil S (1), Garbayo E (1), Díaz-Herráez P (1), Prosper F (2), Blanco-Prieto MJ (3).
(1) Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.
(2) Hematology, Cardiology and Cell Therapy, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain; Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.
(3) Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain 

Revista: Journal of Controlled Released

Fecha: 10-abr-2015

Área de Terapia Celular

RESUMEN

Myocardial infarction causes almost 7.3 million deaths each year worldwide. However, current treatments are more palliative than curative. Presently, cell and protein therapies are considered the most promising alternative treatments.

Clinical trials performed until now have demonstrated that these therapies are limited by protein short half-life and by low transplanted cell survival rate, prompting the development of novel cell and protein delivery systems able to overcome such limitations.

In this review we discuss the advances made in the last 10years in the emerging field of cardiac repair using biomaterial-based delivery systems with focus on the progress made on preclinical in vivo studies.

Then, we focus in cardiac tissue engineering approaches, and how the incorporation of both cells and proteins together into biomaterials has opened new horizons in the myocardial infarction treatment. Finally, the ongoing challenges and the perspectives for future work in cardiac tissue engineering will also be discussed.

CITA DEL ARTÍCULO  J Control Release. 2015 Apr 10;203:23-38. doi: 10.1016/j.jconrel.2015.02.009. Epub 2015 Feb 7.

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra