Publicaciones científicas

Circulating ANGPTL8/Betatrophin Concentrations Are Increased After Surgically Induced Weight Loss, but Not After Diet-Induced Weight Loss

Pascual-Corrales E (1), Gómez-Ambrosi J (2,3,4), Moncada R (3,4,5), Valentí V (3,4,6), Catalán V (2,3,4), Rodríguez A (2,3,4), Ramírez B (3,4), Silva C (1,3,4), Gil MJ (3,4,7), Salvador J (1,3,4), Frühbeck G (8,9,10,11).
(1) Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain.
(2) Metabolic Research Laboratory, University of Navarra, Pamplona, Spain.
(3) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.
(4) Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
(5) Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain.
(6) Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
(7) Department of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain.
(8) Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain. gfruhbeck@unav.es.
(9) Metabolic Research Laboratory, University of Navarra, Pamplona, Spain. gfruhbeck@unav.es.
(10) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.
(11) Obesity & Adipobiology Group, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.

Revista: Obesity Surgery

Fecha: 14-ene-2016

Endocrinología y Nutrición Cirugía General y Digestiva Área de Obesidad Anestesia y Cuidados Intensivos

BACKGROUND

ANGPTL8/betatrophin is a secreted protein reported to be involved in β-cell replication that has recently been shown to be more related to lipid metabolism. Weight loss represents a clinical situation of improvement of glucose homeostasis and overall metabolic control.

The aim of the present study was to analyze the impact of weight loss induced by either a conventional dietary treatment or bariatric surgery on ANGPTL8/betatrophin concentrations.

METHODS

Serum concentrations of ANGPTL8/betatrophin were measured by ELISA in 158 subjects before and 1 year after weight loss induced either by conventional dietary treatment (n = 38) or bariatric surgery (sleeve gastrectomy, n = 20, or Roux-en-Y gastric bypass, n = 100).

RESULTS

Massive surgery-induced weight loss after SG or RYGB was accompanied by a statistically significant increase in circulating levels of ANGPTL8/betatrophin (28.1 ± 13.9 to 40.3 ± 22.8 ng/mL, P = 0.001 after SG; 24.6 ± 10.9 to 41.7 ± 19.4 ng/mL, P < 0.001 after RYGB), while remaining unchanged 25.6 ± 13.3 to 25.4 ± 10.7 ng/mL (P = 0.891) after diet-induced weight loss. The change in ANGPTL8/betatrophin levels was positively correlated with the change in HDL-C concentrations.

CONCLUSIONS

Our study showed that serum ANGPTL8/betatrophin concentrations were increased in obese subjects after surgically induced weight loss, but not after weight loss achieved by conventional dietary treatment. The change in ANGPTL8/betatrophin concentrations emerged as a significant predictor of the change in HDL-C levels after weight loss.

CITA DEL ARTÍCULO  Obes Surg. 2016 Jan 14

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