Publicaciones científicas

Transplantation of Mesenchymal Stem Cells exerts a greater long-term effect than Bone Marrow Mononuclear Cells in a chronic myocardial infarction model in rat

Mazo M, Gavira JJ, Abizanda G, Moreno C, Ecay M, Soriano M, Aranda P, Collantes M, Alegría E, Merino J, Peñuelas IN, Verdugo JM, Pelacho B, Prosper F.

Revista: Cell Transplantation

Fecha: 16/11/2009

Medicina Nuclear Inmunología e Inmunoterapia Cardiología Área de Terapia Celular

Aims
To assess the long-term effect of mesenchymal stem cells (MSC) transplantation in a rat model of chronic myocardial infarction (MI) in comparison with the effect of bone marrow mononuclear cells (BM-MNC) transplant.

Materials and Methods
5 weeks after induction of MI, rats were allocated to receive intramyocardial injection of 10 GFP-expressing cells (BM-MNC or MSC) or medium as control. Heart function (echocardiography and (1)F-FDG-microPET) and histological studies were performed 3 months after transplantation and cell fate was analyzed along the experiment (1, 2 weeks and 1, 3 months).

Results
The main findings of this study were that both BM-derived populations, BM-MNC and MSC, induced a long-lasting (3 months) improvement in LVEF (BM-MNC: 26.61 +/- 2.01% to 46.61 +/- 3.7%, P<0.05; MSC: 27.5 +/- 1.28% to 38.8 +/- 3.2%, P<0.05) but remarkably, only MSC improved tissue metabolism quantified by (1)F-FDG uptake (71.15 +/- 1.27 to 76.31 +/- 1.11, P<0.01) which was thereby associated with a smaller infarct size and scar collagen content and also, with a higher revascularization degree.

Conclusions
Altogether, results show that MSC provides a long-term superior benefit than whole BM-MNC transplantation in a rat model of chronic MI.

CITA DEL ARTÍCULO  Cell Transplant. 2010;19(3):313-28

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra