Publicaciones científicas

The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits

Obeso J.A., Rodríguez-Oroz M., Marín C., Alonso F., Zamarbide I., Lanciego J.L., Rodríguez-Díaz M.
Department of Neurology and Neurosurgery, Neuroscience Center, FIMA, Clínica Universitaria and Medical School, University of Navarra, Pamplona, Spain.

Revista: Neurology

Fecha: 01/01/2004

Neurología

The severity of dopamine depletion and the consequent pathophysiologic changes that occur in basal ganglia circuits determine the severity of parkinsonian signs.

Restoring the dopamine deficit or the downstream physiologic abnormalities improves Parkinson's Disease (PD) main motor features and as a result, attenuates the short-duration response (SDR). Therefore, both the magnitude and duration of the motor response are a function of the degree of motor severity, which is primarily governed by the loss of tonic dopaminergic activity and disruption of basal ganglia homeostatic mechanisms among which the STN-GPe/GPi circuits play a fundamental role.

As neurodegeneration advances, standard levodopa administration give rises to wider oscillations in striatal dopamine availability and pulsatile stimulation of striatal dopamine receptors becomes predominant. This induces molecular and physiologic changes that further accentuate and aggravate the SDR that sustains motor fluctuations.

Treatments capable of providing and restoring more tonic and physiologic dopaminergic stimulation may avoid many of these abnormalities and lead to better clinical outcomes.

CITA DEL ARTÍCULO  Neurology. 2004 Jan 13;62(1 Suppl 1):S17-30

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra